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C-Reactive Protein, High Sensitivity (hs-CRP)

Test ID: A882

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C-reactive protein (CRP) concentration rises non-specifically in response to inflammation. Measurements of CRP are useful for detecting infections and other medical conditions. A high-sensitivity C-reactive protein (hs-CRP) test is a very sensitive test that is useful for detecting small increases, which can be indicative of an increased risk of coronary artery disease.



How to order a test


  • Cardiac C-Reactive Protein
  • CRP
  • hs-CRP
  • High-sensitivity CRP

What is Included?

Measurement of C-reactive protein by high sensitivity assay to aid in the assessment of cardiac health and inflammation.

Turnaround Time

1 – 3 business days
The turnaround time is not guaranteed. The average turnaround time is 1 – 3 business days from the date that the sample arrives at the laboratory. Shipping time for the sample is not included. Additional time is required if the case requires confirmatory or reflex testing, or if the sample is insufficient, or if a recollection is required.

Related Documents

Additional Information and Resources


Preparation Before Specimen Collection

C-reactive protein (CRP) levels rise nonspecifically in response to infection, inflammation, injury, surgery, and strenuous exercise (e.g., marathon running). For an accurate interpretation of CRP levels (particularly in relation to cardiovascular risk), please wait at least two weeks after any of these factors before collecting a blood sample for this test.

For an accurate assessment of cardiovascular risk, it is recommended that two samples are collected, two weeks apart in metabolically stable people. Any results >10 mg/L should be disregarded for a cardiovascular risk assessment and alternative sources of inflammation or infection should be investigated.

No fasting is required prior to collecting the blood sample for this test.

Specimen Type



50 μL in a microtainer


Microtainer (regular blood tube)

Collection Method

This test requires a blood sample from a finger prick. All supplies for sample collection are provided in the kit.

  1. First wash and dry hands. Warm hands aid in blood collection.
  2. Clean the finger prick site with the alcohol swab and allow to air dry.
  3. Use the provided lancet to puncture the skin in one quick, continuous and deliberate stroke.
  4. Wipe away the first drop of blood.
  5. Massage hand and finger to increase blood flow to the puncture site. Angle arm and hand downwards to facilitate blood collection on the fingertip.
  6. Drip blood into the microtainer tube.
  7. Dispose of all sharps safely and return sample to the laboratory in the provided prepaid return shipping envelope.

NOTES: Avoid squeezing or ‘milking’ the finger excessively. If more blood is required and blood flow stops, perform a second skin puncture on another finger. Do not touch the fingertip.

Specimen Storage

Maintain specimen at temperatures between 2°C and 30°C during storage and transport.

Specimen Stability

Blood samples can be refrigerated or kept at room temperature for up to 7 days.

Causes for Rejection

  • Incorrect or incomplete patient identification
  • Incorrect specimen collection
  • Inappropriate storage and transport conditions
  • Incorrect specimen volume
  • Gross lipemia



To measure C-reactive protein (CRP) levels in a blood sample for the evaluation of cardiac health and inflammation.


  • This report is not intended for use in medico-legal applications. 
  • These results should be interpreted in conjunction with other laboratory and clinical information.
  • Correct specimen collection and handling is required for optimal assay performance. 
  • Interferences from medication or endogenous substances may affect results.
  • This CRP assay is not a substitute for traditional cardiovascular risk factors.
  • This CRP assay should not be used solely for acute coronary syndrome management.
  • CRP levels can also be elevated in noncardiovascular etiologies.
  • Gammopathy, particularly of the monoclonal IgM type may interfere with this assay.


Turbidimetric/Immunoturbidometric (Alinity c CRP Vario assay)

Reference Intervals

  Average hs-CRP level (mg/L)
Low risk of cardiovascular disease < 1.00¹
Average risk of cardiovascular disease 1.00 – 3.00¹
High risk of cardiovascular disease > 3.00¹
Indicative of acute inflammation > 5.00²

These reference ranges were obtained from:
¹. Pearson et al. (2003) from the Centers for Disease Control and Prevention (CDC) and American Heart Association.
². Dati F, Johnson AM, Whicher JT. The existing interim consensus reference ranges and the future approach. Clin Chem Lab Med. 2001 Nov;39(11):1134-6. PMID: 11831629.