Promiscuity Gene DRD4 Test
$180
Are you more likely to be unfaithful, because of your genes?
Find out if have the “promiscuity” gene with this DNA test.
- Analyzes the RS3 repeat region in the DRD4 gene
- People who inherit at least one allele of 7 or more repeats (7R+) are more likely to be sexually promiscuous
- 100% private and confidential online results
- Do you have the “promiscuity” DRD4 gene?
DESCRIPTION
The “promiscuity” gene is a genetic variant of the DRD4 gene, associated with an increased likelihood of sexual promiscuity.
Dopamine is a neurotransmitter or a chemical made in the brain that gives us feelings of reward and pleasure. The dopamine receptor D4, encoded by the DRD4 gene, binds dopamine and transmits the signal into the cells.
The “promiscuity” gene is also known as the 7R+ version of the dopamine receptor. Altered receptors encoded by these variants bind dopamine less efficiently, compared to the common 4R version. As a result, reduced levels of the dopamine “feel good” signal is transmitted in the brain.
People with the 7R+ variants require higher levels of dopamine to achieve the same “good feeling” affects, and intriguingly sexual activity is a proven way to increase dopamine levels.
THE GENETICS
The DRD4 gene is located on chromosome 11. Inheriting a “promiscuity” variant (7R+), is associated with increased promiscuity and an increased number of extra-pair partners.
VariantsTested
Variation in DRD4 often occurs in a 48-base pair repeat region, where the number of repeats can range from 2 – 11.
We inherit two copies of the DRD4 gene – one from each parent. This mean we can inherit two identical copies (e.g. both 4R) or two different copies (e.g. 4R and 7R).
This test determines the length of the repeat region within the DRD4 gene, and specifies the number of repeats an individual has in each of their DRD4 alleles.
If an individual has at least one copy of the 7R+ allele (includes 7R, 8R, 9R, 10R and 11R), they are twice as likely to be promiscuous compared to individuals with 7R- alleles (less than 7 repeats).
OTHER CONDITIONS ASSOCIATED WITH THE AVPR1A GENE
The most common DRD4 variant worldwide is the 4R version and approximately 65% of the population carry this version. The 7R form is the next most common (20%), followed by the 2R allele (9%). The other alleles are less common, especially the very rare alleles that have eight or more repeats (less than 1%).
The allele frequency also varies significantly between populations. For example, the “promiscuous” 7R allele is rare in East and South Asian populations, but common in the Americas.
FEE SCHEDULE FOR YEAR 2020
1 child, 1 alleged father
$99
$230
1 mother, 1 child, 1 alleged father
$139
$255
2 children, 1 alleged father
$164
$325
1 mother, 2 children, 1 alleged father
$210
$350
3 children, 1 alleged father
$249
$420
1 mother, 3 children, 1 alleged father
$295
$445
4 children, 1 alleged father
$334
$515
1 mother, 4 children, 1 alleged father
$380
$540
5 children, 1 alleged father
$419
$610
1 mother, 1 child, 2 alleged fathers
$210
$350
6 children, 1 alleged father
$504
$705
1 child, 2 alleged fathers
$164
$325
For legal testing, a specimen collection and witnessing charge of $50 will apply for each individual whose sample is collected at one of our locations in the US, and $100 for each individual whose sample is collected overseas. A $25 charge will apply if individuals in the same case are collected at different locations.
HOW IT WORKS
Step 1: Order test kit online
Step 2: Collect DNA sample using a painless mouth swab, and mail to the lab in the provided return envelope
Step 3: Receive your results online
DESCRIPTION
Serotonin is a neurotransmitter in the brain that gives us feelings of pleasure and well-being. When serotonin is released from cells in the brain (neurons), it sends out signals to be happy and content.
The serotonin transporter moves serotonin from the synaptic cleft into the presynaptic neuron, allowing serotonin recycling in a sodium-dependent manner. It is also important for maintaining functional neural circuits that connect the amygdala and the cingulate regions of the brain.
People with the “grouchy” gene produce lower levels of the serotonin transporter, and have smaller amygdala and cingulate regions – two brain regions involved in emotional responses.
These changes result in an increased likelihood of anxiety and depression in people with one or more copies of the “grouchy” gene. It may also reduce the response to commonly used selective serotonin reuptake inhibitors (SSRI antidepressants).
A simple mouth swab is all you need to find out if you have the “grouchy” gene.
THE GENETICS
This DNA test determines the length of the 5-HTTLPR region of the SLC64A gene. It distinguishes between the short (S) or “grouchy” form and the long (L) form of the gene.
VariantsTested
The SLC6A4 gene is located on chromosome 17. We inherit two copies of this gene – one from each parent. Inheriting one or two copies of the short (“grouchy”) form is linked to an increased risk of depression.
- People with two copies of the short, “grouchy” form are more likely to be unhappy. They will pass this form of the SLC6A4 gene to all of their children.
- People with two copies of the long form, have a decreased risk of unhappiness and depression.
- Heterozygotes have one copy of the long form and one copy of the short form. Having one copy of the “grouchy” gene also affects the level of happiness. These people have a 50% chance of passing the grouchy gene to their children.
RESPONSE TO ANTIDEPRESSANTS
Selective serotonin reuptake inhibitors (SSRIs) are antidepressants that are commonly used as first-line treatment of depression. Examples include Prozac, Zoloft and Paxil. However, 30-40% of affected people do not appear to benefit as well from these treatments.
The “grouchy” version of the SLC6A4 gene may explain some of this variation, as it is associated with a decreased response to SSRIs.
The molecular target of SSRIs is the 5-HTT serotonin transporter protein. People with the “grouchy” gene produce lower levels of this protein, therefore, they have a lower number of SSRI targets, which affects the efficacy of these commonly prescribed antidepressants.
Alternative antidepressants may be recommended for patients carrying the “grouchy” gene.
HOW IT WORKS
Step 1: Order test kit online
Step 2: Collect DNA sample using a painless mouth swab, and mail to the lab in the provided return envelope
Step 3: Receive your results online